{"id":1798,"date":"2026-06-22T14:23:08","date_gmt":"2026-06-22T07:23:08","guid":{"rendered":"https:\/\/atlanticmedical.vn\/?p=1798"},"modified":"2026-06-22T15:38:26","modified_gmt":"2026-06-22T08:38:26","slug":"tu-e-coli-asparaginase-den-erwinase-giai-phap-duy-tri-lieu-phap-asparaginase-cho-benh-nhan-mac-benh-bach-cau-cap-dong-lympho-all-va-u-lympho-nguyen-bao-lympho-lbl","status":"publish","type":"post","link":"https:\/\/atlanticmedical.vn\/en\/tu-e-coli-asparaginase-den-erwinase-giai-phap-duy-tri-lieu-phap-asparaginase-cho-benh-nhan-mac-benh-bach-cau-cap-dong-lympho-all-va-u-lympho-nguyen-bao-lympho-lbl\/","title":{"rendered":"T\u1eeb E. coli Asparaginase \u0111\u1ebfn Erwinase: Gi\u1ea3i ph\u00e1p duy tr\u00ec li\u1ec7u ph\u00e1p Asparaginase cho b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh b\u1ea1ch c\u1ea7u c\u1ea5p d\u00f2ng Lympho (ALL) v\u00e0 u lympho nguy\u00ean b\u00e0o lympho (LBL)\u00a0\u00a0"},"content":{"rendered":"

Asparaginase \u2013 m\u1ed9t trong nh\u1eefng n\u1ec1n t\u1ea3ng c\u1ee7a \u0111i\u1ec1u tr\u1ecb ALL hi\u1ec7n \u0111\u1ea1i <\/strong><\/h2>\n\n\n\n
    <\/ol>\n\n\n\n

    Trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u lymphoblastic c\u1ea5p (Acute Lymphoblastic Leukemia \u2013 ALL) v\u00e0 lymphoma lymphoblastic (LBL), asparaginase \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c quan tr\u1ecdng nh\u1ea5t gi\u00fap c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 lui b\u1ec7nh v\u00e0 s\u1ed1ng c\u00f2n l\u00e2u d\u00e0i. <\/p>\n\n\n\n

    Kh\u00e1c v\u1edbi h\u00f3a tr\u1ecb truy\u1ec1n th\u1ed1ng, asparaginase ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch th\u1ee7y ph\u00e2n asparagine trong huy\u1ebft t\u01b0\u01a1ng th\u00e0nh aspartic acid v\u00e0 ammonia. S\u1ef1 thi\u1ebfu h\u1ee5t asparagine khi\u1ebfn t\u1ebf b\u00e0o lymphoblast \u00e1c t\u00ednh kh\u00f4ng th\u1ec3 t\u1ed5ng h\u1ee3p protein c\u1ea7n thi\u1ebft cho s\u1ef1 s\u1ed1ng c\u00f2n v\u00e0 t\u0103ng sinh. <\/p>\n\n\n\n

    Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng vi\u1ec7c duy tr\u00ec \u0111\u1ea7y \u0111\u1ee7 li\u1ec7u ph\u00e1p asparaginase l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 quan tr\u1ecdng g\u00f3p ph\u1ea7n n\u00e2ng t\u1ef7 l\u1ec7 s\u1ed1ng th\u00eam d\u00e0i h\u1ea1n \u1edf b\u1ec7nh nh\u00e2n ALL l\u00ean tr\u00ean 80\u201390%.  <\/p>\n\n\n\n

    S\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c th\u1ebf h\u1ec7 Asparaginase <\/h2>\n\n\n\n
      <\/ol>\n\n\n\n

      Native E. coli L-asparaginase l\u00e0 ch\u1ebf ph\u1ea9m \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng v\u1edbi hi\u1ec7u qu\u1ea3 ch\u1ed1ng b\u1ea1ch c\u1ea7u cao v\u00e0 \u0111\u1eb7t n\u1ec1n m\u00f3ng cho c\u00e1c ph\u00e1c \u0111\u1ed3 ALL hi\u1ec7n \u0111\u1ea1i. Tuy nhi\u00ean h\u1ea1n ch\u1ebf c\u1ee7a thu\u1ed1c l\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i ng\u1eafn khi\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng nhi\u1ec1u l\u1ea7n v\u00e0 t\u00ednh t\u0103ng sinh mi\u1ec5n d\u1ecbch \u0111\u00e3 th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c th\u1ebf h\u1ec7 ti\u1ebfp theo b\u1eb1ng c\u00e1ch g\u1eafn polyethylene glycol (PEG) v\u00e0o enzyme c\u00f3 ngu\u1ed3n g\u1ed1c E. coli. T\u1eeb \u0111\u00f3 t\u1ea1o ra th\u1ebf h\u1ec7 Pegaspargase, Calaspargase pegol gi\u00fap k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n th\u1ea3i t\u1eeb v\u00e0i ng\u00e0y l\u00ean nhi\u1ec1u ng\u00e0y, gi\u1ea3m s\u1ed1 l\u1ea7n ti\u00eam, Gi\u1ea3m t\u1ef7 l\u1ec7 qu\u00e1 m\u1eabn so v\u1edbi native E. coli asparaginase. <\/p>\n\n\n\n

      Nh\u1edd nh\u1eefng \u01b0u \u0111i\u1ec3m n\u00e0y, PEG -asparaginase \u0111\u00e3 tr\u1edf th\u00e0nh l\u1ef1a ch\u1ecdn ti\u00eau chu\u1ea9n trong nhi\u1ec1u ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb hi\u1ec7n nay. <\/p>\n\n\n\n

      Tuy nhi\u00ean, PEG-asparaginase v\u1eabn mang ngu\u1ed3n g\u1ed1c kh\u00e1ng nguy\u00ean t\u1eeb E. coli. V\u00ec v\u1eady, khi b\u1ec7nh nh\u00e2n \u0111\u00e3 h\u00ecnh th\u00e0nh kh\u00e1ng th\u1ec3 ch\u1ed1ng l\u1ea1i E. coli-derived asparaginase, thu\u1ed1c v\u1eabn c\u00f3 th\u1ec3 b\u1ecb m\u1ea5t ho\u1ea1t t\u00ednh ho\u1eb7c g\u00e2y ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn. <\/p>\n\n\n\n

      Th\u00e1ch th\u1ee9c l\u00e2m s\u00e0ng: Kh\u00f4ng ph\u1ea3i m\u1ecdi b\u1ec7nh nh\u00e2n \u0111\u1ec1u c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c s\u1eed d\u1ee5ng Asparaginase ngu\u1ed3n g\u1ed1c E. coli <\/h2>\n\n\n\n
        <\/ol>\n\n\n\n

        M\u1eb7c d\u00f9 PEG-asparaginase \u0111\u00e3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 kh\u1ea3 n\u0103ng dung n\u1ea1p, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nh\u01b0ng v\u1eabn l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn nh\u1ea5t d\u1eabn \u0111\u1ebfn gi\u00e1n \u0111o\u1ea1n li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb asparaginase do t\u1ef7 l\u1ec7 qu\u00e1 m\u1eabn v\u1edbi native E. coli asparaginase th\u01b0\u1eddng \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0 30%, v\u00e0 tr\u00ean 30% t\u00f9y ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb. V\u00e0 ngay c\u1ea3 v\u1edbi PEG-asparaginase, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1eabn c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf m\u1ed9t t\u1ef7 l\u1ec7 b\u1ec7nh nh\u00e2n nh\u1ea5t \u0111\u1ecbnh.  <\/p>\n\n\n\n

        \u0110i\u1ec1u n\u00e0y \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c c\u1ee9 kho\u1ea3ng 4\u20135 b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng asparaginase ngu\u1ed3n g\u1ed1c E. coli s\u1ebd c\u00f3 1 b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c xem x\u00e9t chuy\u1ec3n sang m\u1ed9t l\u1ef1a ch\u1ecdn thay th\u1ebf. <\/p>\n\n\n\n

        Nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 qu\u00e1 m\u1eabn cao h\u01a1n <\/h3>\n\n\n\n

        B\u1ec7nh nh\u00e2n c\u00f3 kho\u1ea3ng ngh\u1ec9 \u0111i\u1ec1u tr\u1ecb d\u00e0i<\/em> <\/h4>\n\n\n\n

        Nguy c\u01a1 qu\u00e1 m\u1eabn t\u0103ng \u0111\u00e1ng k\u1ec3 khi b\u1ec7nh nh\u00e2n ng\u1eebng s\u1eed d\u1ee5ng asparaginase trong th\u1eddi gian d\u00e0i r\u1ed3i ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb tr\u1edf l\u1ea1i. Trong th\u1eddi gian ng\u1eebng thu\u1ed1c, c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh c\u00e1c kh\u00e1ng th\u1ec3 ch\u1ed1ng l\u1ea1i enzyme, d\u1eabn \u0111\u1ebfn ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh h\u01a1n khi t\u00e1i s\u1eed d\u1ee5ng. <\/p>\n\n\n\n

        B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed ti\u1ebfp x\u00fac v\u1edbi asparaginase <\/em> <\/h4>\n\n\n\n

        Nguy c\u01a1 t\u0103ng l\u00ean khi b\u1ec7nh nh\u00e2n \u0111\u00e3 t\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c tr\u01b0\u1edbc \u0111\u00f3. <\/p>\n\n\n\n

        B\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng native E. coli Asparaginase<\/em> <\/h4>\n\n\n\n

        Native E. coli asparaginase c\u00f3 t\u1ef7 l\u1ec7 qu\u00e1 m\u1eabn cao h\u01a1n PEG-asparaginase do t\u00ednh sinh mi\u1ec5n d\u1ecbch cao h\u01a1n. <\/p>\n\n\n\n

        Silent Inactivation (B\u1ea5t ho\u1ea1t th\u1ea7m l\u1eb7ng) \u2013 Th\u00e1ch th\u1ee9c th\u01b0\u1eddng b\u1ecb b\u1ecf s\u00f3t<\/em> <\/h4>\n\n\n\n

        Kh\u00f4ng ph\u1ea3i m\u1ecdi tr\u01b0\u1eddng h\u1ee3p m\u1ea5t hi\u1ec7u qu\u1ea3 asparaginase \u0111\u1ec1u bi\u1ec3u hi\u1ec7n b\u1eb1ng d\u1ecb \u1ee9ng l\u00e2m s\u00e0ng. M\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n h\u00ecnh th\u00e0nh kh\u00e1ng th\u1ec3 trung h\u00f2a thu\u1ed1c nh\u01b0ng ho\u00e0n to\u00e0n kh\u00f4ng xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng. Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 “silent inactivation” – b\u1ea5t ho\u1ea1t th\u1ea7m l\u1eb7ng. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y thu\u1ed1c v\u1eabn \u0111\u01b0\u1ee3c ti\u1ebfp t\u1ee5c s\u1eed d\u1ee5ng, b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u d\u1ecb \u1ee9ng tuy nhi\u00ean ho\u1ea1t t\u00ednh enzyme \u0111\u00e3 gi\u1ea3m xu\u1ed1ng d\u01b0\u1edbi ng\u01b0\u1ee1ng \u0111i\u1ec1u tr\u1ecb. K\u1ebft qu\u1ea3 l\u00e0 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 kh\u00f4ng nh\u1eadn \u0111\u01b0\u1ee3c \u0111\u1ea7y \u0111\u1ee7 l\u1ee3i \u00edch t\u1eeb li\u1ec7u ph\u00e1p asparaginase. <\/p>\n\n\n\n

        \u0110\u00e2y l\u00e0 l\u00fd do ng\u00e0y c\u00e0ng nhi\u1ec1u h\u01b0\u1edbng d\u1eabn qu\u1ed1c t\u1ebf khuy\u1ebfn kh\u00edch theo d\u00f5i ho\u1ea1t t\u00ednh asparaginase trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. <\/p>\n\n\n\n

        S\u1ef1 ra \u0111\u1eddi c\u1ee7a Erwinase \u2013 Gi\u1ea3i ph\u00e1p cho b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn v\u1edbi E. coli-derived Asparaginase\u00a0<\/strong><\/h2>\n\n\n\n

        \u0110\u1ec3 gi\u1ea3i quy\u1ebft nhu c\u1ea7u \u0111i\u1ec1u tr\u1ecb c\u1ee7a nh\u00f3m b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 ti\u1ebfp t\u1ee5c s\u1eed d\u1ee5ng c\u00e1c ch\u1ebf ph\u1ea9m ngu\u1ed3n g\u1ed1c E. coli, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 ph\u00e1t tri\u1ec3n Erwinase L-asparaginase (Crisantaspase). <\/p>\n\n\n\n

        Erwinase \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1eeb vi khu\u1ea9n Erwinia chrysanthemi<\/em> (nay \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 Dickeya dadantii<\/em>), kh\u00e1c ho\u00e0n to\u00e0n v\u1edbi ngu\u1ed3n g\u1ed1c E. coli c\u1ee7a c\u00e1c ch\u1ebf ph\u1ea9m tr\u01b0\u1edbc \u0111\u00f3. <\/p>\n\n\n\n

        Do c\u1ea5u tr\u00fac kh\u00e1ng nguy\u00ean kh\u00e1c bi\u1ec7t, c\u00e1c kh\u00e1ng th\u1ec3 ch\u1ed1ng E. coli-derived asparaginase th\u01b0\u1eddng kh\u00f4ng ph\u1ea3n \u1ee9ng ch\u00e9o \u0111\u00e1ng k\u1ec3 v\u1edbi Erwinase. <\/p>\n\n\n\n

        Nh\u1edd v\u1eady, Erwinase c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c duy tr\u00ec ho\u1ea1t t\u00ednh l\u00e0m c\u1ea1n ki\u1ec7t asparagine \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 xu\u1ea5t hi\u1ec7n qu\u00e1 m\u1eabn ho\u1eb7c b\u1ea5t ho\u1ea1t thu\u1ed1c khi s\u1eed d\u1ee5ng E. coli-derived asparaginase. <\/p>\n\n\n\n

        B\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng v\u1ec1 Erwinase<\/em> <\/h4>\n\n\n\n

        M\u1ed9t nghi\u00ean c\u1ee9u c\u1ee7a Dana-Farber Cancer Institute tr\u00ean 215 b\u1ec7nh nhi m\u1eafc ALL ghi nh\u1eadn:<\/em> <\/p>\n\n\n\n

          \n
        • 45 b\u1ec7nh nh\u00e2n (21%) xu\u1ea5t hi\u1ec7n d\u1ecb \u1ee9ng v\u1edbi E. coli-derived asparaginase.<\/em> <\/li>\n<\/ul>\n\n\n\n
            \n
          • 42 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c chuy\u1ec3n sang Erwinase.<\/em> <\/li>\n<\/ul>\n\n\n\n
              \n
            • 89% b\u1ec7nh nh\u00e2n \u0111\u1ea1t \u0111\u01b0\u1ee3c ho\u1ea1t t\u00ednh asparaginase \u1edf ng\u01b0\u1ee1ng \u0111i\u1ec1u tr\u1ecb.<\/em> <\/li>\n<\/ul>\n\n\n\n
                \n
              • 81% b\u1ec7nh nh\u00e2n ho\u00e0n th\u00e0nh t\u1ed1i thi\u1ec3u 26 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb asparaginase theo k\u1ebf ho\u1ea1ch.<\/em> <\/li>\n<\/ul>\n\n\n\n

                \u0110\u1eb7c bi\u1ec7t, t\u1ef7 l\u1ec7 s\u1ed1ng c\u00f2n kh\u00f4ng bi\u1ebfn c\u1ed1 (Event-Free Survival \u2013 EFS) \u1edf nh\u00f3m chuy\u1ec3n sang Erwinase t\u01b0\u01a1ng \u0111\u01b0\u01a1ng nh\u00f3m kh\u00f4ng xu\u1ea5t hi\u1ec7n d\u1ecb \u1ee9ng.<\/em> <\/p>\n\n\n\n

                Nh\u1eefng d\u1eef li\u1ec7u n\u00e0y cho th\u1ea5y vi\u1ec7c chuy\u1ec3n sang Erwinase gi\u00fap b\u1ec7nh nh\u00e2n ti\u1ebfp t\u1ee5c nh\u1eadn \u0111\u01b0\u1ee3c l\u1ee3i \u00edch c\u1ee7a li\u1ec7u ph\u00e1p asparaginase m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i.<\/em> <\/p>\n\n\n\n

                B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 trong c\u00f4ng ngh\u1ec7 sinh h\u1ecdc m\u1edbi: Erwinia Asparaginase t\u00e1i t\u1ed5 h\u1ee3p <\/h2>\n\n\n\n

                Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, c\u00f4ng ngh\u1ec7 sinh h\u1ecdc \u0111\u00e3 cho ph\u00e9p ph\u00e1t tri\u1ec3n c\u00e1c ch\u1ebf ph\u1ea9m Erwinia-derived asparaginase t\u00e1i t\u1ed5 h\u1ee3p. <\/p>\n\n\n\n

                Kh\u00e1c v\u1edbi Erwinase truy\u1ec1n th\u1ed1ng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t tr\u1ef1c ti\u1ebfp t\u1eeb qu\u00e1 tr\u00ecnh nu\u00f4i c\u1ea5y vi khu\u1ea9n, c\u00e1c ch\u1ebf ph\u1ea9m t\u00e1i t\u1ed5 h\u1ee3p \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng c\u00f4ng ngh\u1ec7 DNA t\u00e1i t\u1ed5 h\u1ee3p gi\u00fap \u1ed5n \u0111\u1ecbnh ngu\u1ed3n cung h\u01a1n \u0111\u1ed3ng th\u1eddi \u0111\u1ea3m b\u1ea3o t\u00ednh \u0111\u1ed3ng nh\u1ea5t gi\u1eefa c\u00e1c l\u00f4 thu\u1ed1c trong khi v\u1eabn duy tr\u00ec \u0111\u1eb7c t\u00ednh mi\u1ec5n d\u1ecbch h\u1ecdc t\u01b0\u01a1ng t\u1ef1 Erwinia-derived asparaginase. <\/p>\n\n\n\n

                M\u1ed9t v\u00ed d\u1ee5 ti\u00eau bi\u1ec3u l\u00e0 Erwinia L-asparaginase t\u00e1i t\u1ed5 h\u1ee3p (Enrylaze), \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n nh\u1eb1m gi\u1ea3i quy\u1ebft t\u00ecnh tr\u1ea1ng thi\u1ebfu h\u1ee5t ngu\u1ed3n cung Erwinase t\u1eebng x\u1ea3y ra t\u1ea1i nhi\u1ec1u qu\u1ed1c gia. <\/p>\n\n\n\n

                Vai tr\u00f2 c\u1ee7a Erwinase trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng hi\u1ec7n nay <\/h2>\n\n\n\n

                M\u1eb7c d\u00f9 nhi\u1ec1u c\u1ea3i ti\u1ebfn c\u00f4ng ngh\u1ec7 \u0111\u00e3 xu\u1ea5t hi\u1ec7n, nhu c\u1ea7u v\u1ec1 Erwinia-derived asparaginase v\u1eabn ti\u1ebfp t\u1ee5c gia t\u0103ng tr\u00ean to\u00e0n c\u1ea7u. <\/p>\n\n\n\n

                \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n qu\u00e1 m\u1eabn ho\u1eb7c b\u1ea5t ho\u1ea1t th\u1ea7m l\u1eb7ng khi s\u1eed d\u1ee5ng c\u00e1c ch\u1ebf ph\u1ea9m ngu\u1ed3n g\u1ed1c E. coli, Erwinase \u0111\u00f3ng vai tr\u00f2 l\u00e0 gi\u1ea3i ph\u00e1p thay th\u1ebf gi\u00fap duy tr\u00ec li\u1ec7u ph\u00e1p asparaginase, h\u1ea1n ch\u1ebf gi\u00e1n \u0111o\u1ea1n \u0111i\u1ec1u tr\u1ecb v\u00e0 h\u1ed7 tr\u1ee3 b\u1ec7nh nh\u00e2n ho\u00e0n th\u00e0nh \u0111\u1ea7y \u0111\u1ee7 ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb ALL ho\u1eb7c LBL. <\/p>\n\n\n\n

                Trong b\u1ed1i c\u1ea3nh ng\u00e0y c\u00e0ng ch\u00fa tr\u1ecdng c\u00e1 th\u1ec3 h\u00f3a \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u1ed1i \u01b0u h\u00f3a k\u1ebft qu\u1ea3 l\u00e2u d\u00e0i, s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a c\u00e1c ch\u1ebf ph\u1ea9m Erwinia-derived asparaginase \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng, m\u1edf ra c\u01a1 h\u1ed9i ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb, gi\u00fap b\u1ea3o to\u00e0n l\u1ee3i \u00edch c\u1ee7a m\u1ed9t trong nh\u1eefng li\u1ec7u ph\u00e1p quan tr\u1ecdng nh\u1ea5t trong \u0111i\u1ec1u tr\u1ecb ALL v\u00e0 LBL. <\/p>","protected":false},"excerpt":{"rendered":"

                Asparaginase \u2013 m\u1ed9t trong nh\u1eefng n\u1ec1n t\u1ea3ng c\u1ee7a \u0111i\u1ec1u tr\u1ecb ALL hi\u1ec7n \u0111\u1ea1i  Trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u lymphoblastic c\u1ea5p (Acute Lymphoblastic Leukemia \u2013 ALL) v\u00e0 lymphoma lymphoblastic (LBL), asparaginase \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c quan tr\u1ecdng nh\u1ea5t gi\u00fap c\u1ea3i thi\u1ec7n t\u1ef7 l\u1ec7 lui b\u1ec7nh v\u00e0 s\u1ed1ng c\u00f2n l\u00e2u d\u00e0i.  Kh\u00e1c v\u1edbi […]<\/p>","protected":false},"author":2,"featured_media":1805,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[109],"tags":[],"class_list":["post-1798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thong-tin-chuyen-mon"],"acf":[],"_links":{"self":[{"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/posts\/1798","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/comments?post=1798"}],"version-history":[{"count":0,"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/posts\/1798\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/media\/1805"}],"wp:attachment":[{"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/media?parent=1798"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/categories?post=1798"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/atlanticmedical.vn\/en\/wp-json\/wp\/v2\/tags?post=1798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}